MOTS-c (short for Mitochondrial Open Reading Frame of the 12S rRNA-c) is a small peptide produced inside the mitochondria—often called the “powerhouse” of the cell.

It plays an important role in metabolism and energy regulation, helping the body use glucose more efficiently and improving insulin sensitivity. Because of this, it’s commonly studied for potential benefits in fat loss, exercise performance, aging, and metabolic health (like conditions such as insulin resistance or obesity).

In simple terms:

MOTS-c helps your body manage energy better and stay metabolically efficient.